Abstract:
In this work the interaction energies between the different types of bases of
a single strand of DNA molecule are calculated. Using these original values
of energies the harmonic behavior of a number of base patterns of DNA
are studied. In view of the great interest aroused by the discovery ofth~e --- of-t-he-te-lo-me~re -~s-e-g--m" e~nt -of the DNA in the replication process and its -- -- ---
possible link with the aging process, -w-e have in.-v-e-s~t.i-g-ated, with simple --" "- ,. ~'"
models, the harmonic behavior of the telomeric pattern of bases as well as \
thethermodynamic respons~~ the bio~o_gic~lsy..s!em.With these;e~lts a
conclusion on the probable role of the telomeric Rattern on aging has also \
been drawn. Here the calculated values of harmonic frequencies of the
telomeric pattern of bases and of other possible patterns show that the
telomeric pattern is associated with the highest vibrational frequency
among all patterns of base combinations at the replication end of DNA.
This seems to suggest that due to the existing telomeric pattern being '\
closest to the frequencies of the electromagnetic radiation coming from
sunlight, resonance of the telomeric frequency with such radiation may be
responsible for damage to the reproductive ability of the cells and
consequent aging and other problems. On the other hand in the last part of
this work we have calculated the thermal vibrational amplitudes of the
telomeric pattern and other possible patterns which show that the
amplitudes for the telomeric pattern is the least, and this suggests that the
telomeric pattern is more mechanically and thermally stable than other
possible patterns in the biological environment against damage from
ordinary heat and mechanical effects.