Studies of some novel astatistical factors stabilising ternary complexes

Abstract

Extensive research work on the determination of stability constants of complex compounds have been carried out .The present work was undertaken with the objective of the determination of stability constants of ternary complexes containing biologically important ligands. The purpose of my present research work is to carefull study in the preparation of such metal complexes. For the preparation of the metal complexes we have used Nickel and Copper and some other important ligands. Folic acid is the primary ligands in every complexes. Folic acid is an important amino acid but the use of the Folic acid as drug as a vitamin B-complex has not been extensively studied in relation to the effects on the health situation. The transition metals have important biological functions in the living system. Therefore, the interaction of the transition metals and the folic acid study in vitro may provide important clue as regard the effects in biological system. Therefore, III the present research work, we have been deteremined the formation constant of ternary complexes of the type [MAL] where M=Cu(II) or Ni(II), A=Folic acid, L=Oxalic acid, Glycine, a-alanine, Malonic acid, Imino diacetic acid, Ethylene diamine, N,N-dimethylene diamine, Dipicolinic acid, 1 t. •....~, . ~ .~' ,.-;. . Tryptophane, Ph-alanine, Adenosine triphosphate, Tyrosine, 1,10 Phenanthrolene, Ortho-phenylene diamine, Para-phenylene diamine. The value of lllogk have been also calculated for the stability of ternary complexes. The Protonation constant, binary constant and ternary constat have been determined potentiometrically USlllg SCOGS (Stability Constant of Generalised Species) computer programme and the formation of the complexes have been confirmed by cyclic voltammogram (CV) and U.V.spectral studies.