Abstract:
In the view of the extensive biological activities of various 6-substilUted uraeiis
and related pyrimidine derivative~, a facile method for the synthesis of a number
of 6- disuostitu(ed pyrimidines were developed (Schelne-I). 2,4-Dichloro
pyrimidine -6-carbonyJ chloride 2 Vias synthesi;.<edby rdluxing Orotic acid I
with phosphorus oxychloride and phosphorus pentaehloride. Compound 2
undem'ent substitution reaction with different substituted aromatic mnines to
give 2, 4 - DiehIoro - 6- substituted phenylamido pyrimidine 10-14. 2, 4 _
Dichloro - 6- substituted phcnylamido pyrimidines were convcrted to the
corresponding dimethoxy pyrimidine 15.19 on treatment with sodium methoxide
in methanol. The demethylation reaction was attempted by renuxing 2. 4-
dimethoxy phenylamido pyrimidine 15-19 wilh 6N hydrochloric acid gave the
desired products 6-substituted pyrimidine 20-24. The structures of the
synthesized products wcn; established from their analytical und spectroscopic
duta.
