Synthesis of substituted 2 - IODOANILINE and 2 - IODOACETANILIDE

Abstract

In view of the extensive natural occurrence and biological importance of the 2-iodoaniline and 2-iodoacetanilide compound a general and facile method for the synthesis of aryl-iodide derivatives through iodine-cupper(II) acetate in acetic acid, afforded the corresponding iodo compound in the better yield. In this purpose different 2-iodoaniline or acetanilide compounds were synthesized from p or m-substituted aryl amines by iodination reaction (Scheme 1). ...........................