Abstract:
In the view of the extensive biological activities of various 5 and 6.
substituted uracils and related pyrimidine derivatives, a facile method for
the synthesis of a number of 5, 6.disubstituted pyrimidines were developed
(Seheme-l). 2, 4-Dichloropyrimidine-&.carbonyl chloride 2 was
synthesized by refluxing Orotic acid 1 with phosphorus oxychloride and
phosphorus pentachloride. Compound.2 underwent substitute rbaction with
different substituted aromatic amines to give 2, 4 - Dichloro . 6.
substituted pbenylamido pyrimidine 9-14. 2, 4 - dichloro - &. substituted
phenylamido pyrimidines were converted to the correspondin~ dimethoxy
pyrimi.dine 15-19 on treatment with sodium methoxide in methanol. The
bromination reaction was attempted by several methods but only NBSI
TFA.TFAA method gave the desired products 20-23. The structures of the
synthesized products were established from their analytical and
spectroscopic data. ....................................................................................
