Synthesis of substituted indoles by metal mediated reactions

Abstract

In view of the extensive natural occurrence and biological importance of the indole nucleus containing heterocyclic compounds a general and facile method for the synthesis of indole derivatives through palladium catalyzed reaction using Terminal alkyne followed by base catalyzed reactions is reported. In this purpose different 2-iodo acetanilide compounds were synthesized from m~substituted aryl amines by iodination reaction (Seheme- I). ......................................................................................