Abstract:
In view of the extensive natural occurrence and biological importance of the
benzofuran derivatives, it was planned to develop a general and facile method
for the synthesis of dihydrobenzofurans through palladium catalyzed
reactions. A convenient method for the synthesis of 2-alkyl-2, 3-dihydro
benzofuran acetate was developed (13-20) from the reaction of substituted
2-iodophenol (4-9) with acrylic esters (10-12) by a (Ph3P)PdCl2, Et3N system
as shown in scheme-1. ............................ All the synthesized 2-iodophenol, 2,3-dihydrobenzofuran compounds have
been tested for antimicrobial activity against five gram-positive and eight
gram-negative bacteria as well as three human fungal pathogens. All the
synthesized compounds (5,8,9, 13-15 & 17-19) were found comparatively
inhabitant activity against all of the tested organisms, at a dose of 200
mm/disk. But there were some synthesized compounds (4,15 & 18) showed
mild activities against most of the tested compounds.
