Synthesis of functionalized organophosphorus compounds of biological importance

Abstract

Organophosphorus compounds have tremendous importance in the field of food technology, animal foodstuff, pesticides, medical compounds, synthetic polymers, fire retardants and natural products. Nucleophilic Substitutions at the carbon centre is very important topic in organic chemistry. Considerable amount of work have been carried on nucleophilic substitution at the carbon centre but much less is known about nucleophilic substitution at the phosphorus centre. Nucleophilic substitution at the phosphorus centre is very important topic in in organophosphorus chemistry. The nucleophilic substitution at the carbon centre is well established but the mechanism of nucleophilic substitution at phosphorus is not well established. It has grown great interest to study nucleophilic substitutions at phosphorus centre.. In view of the extensive use of organophosphorus compounds we synthesize phosphine oxide from active methylene compounds. -----------------