Palladium catalyzed synthesis of substituted indoline derivatives from 2-idoacetanilides

Abstract

Indoline derivatives are one of the most privileged structure motifs frequently found in natural products, pharmaceuticals, functional materials, and agrochemicals. Synthesis and biological evaluation of indoline derivatives have been a topic of special interest to organic and medicinal chemist. In view of the extensive natural occurrence and biological importance of the indoline derivative nucleus containing heterocyclic compounds a general and facile method for synthesis of indoline derivatives through palladium catalyzed reactions is reported. In this purpose different 2-iodoacetanilide compounds 4-6 were synthesized from m/p-substituted aryl amines 1- 3 by iodination reaction (Scheme-1).................................