Abstract:
Macrocyclic chemistry is a growing area of research in inorganic and
bioinorganic chemistry in view of its biological significance. The studies of
macrocycles have undergone tremendous growth in recent years and their
complexation chemistry with a wide variety of metal ions has been
extensively studied. Macrocyclic complexes are considered to mimic the
synthetic models of metalloporphins and metallocorrins due to their intrinsic
structural properties. Macrocyclic complexes have also received special
attention because of their mixed soft-hard donor charater and versatile
coordination behavior and their pharmacological properties, i.e., toxicity
against bacterial growth. The present work is divided into two parts. Firstly,
preparation and characterization of some macrocyclic complexes of Co(II),
Cd(II) and Zn(II) and secondly, study of their antibacterial activity.
Part-I
In present work some macrocyclic complex compounds of Co(II), Cd(II) and
Zn(II) containing a ligand with tetraoxo tetrahydrazin moiety were prepared
by template condensation of malonodihydrazide(C3H8N4O2 ) with different
aldehydes.
The macrocyclic complexes [Cd(C8N8O4H16)(ClO4)2],
[Cd(C10N8O4H20)(ClO4)2], [Cd(C24N8O4H28)(ClO4)2] and
[Cd(C14N8O4H24)(ClO4)2] (1-4) were prepared by the reaction of
malonodihydrazide, (C3H8N4O2) with cadmium(II) perchlorate hexahydrate
in presence of formaldehyde, acetaldehyde, cinnamaldehyde and
crotonaldehyde respectively in 2:1:2 molar ratio.
The macrocyclic complexes [Co(C8N8O4H16)(ClO4)2] and
[Co(C24N8O4H28)(ClO4)2] (5-6) were prepared by the reaction of
malonodihydrazide(C3H8N4O2), with Co(II) perchlorate hexahydrate in the
presence of formaldehyde and cinnamaldehyde respectively in 2:1:2 molar
ratio. The macrocyclic complexes (1-6) are characterized by elemental analysis,
UV-visible and IR spectral analysis, magnetic moment and conductance
measurements and some other physical properties.
