Abstract:
The synthetic precursor thiadiazole (1) has been synthesized from salicylic acid and
thiosemicarbazide under reflux condition. Condensation of thiadiazole with different substituted
benzaldehydes produces hydrazone (2-7). The reaction of different hydrazones with mercapto
acetic acid in presence of catalytic amount of zinc chloride affords the substituted thiazolidinone
derivatives containing thiadiazoline moiety (8-13). All the synthesized compounds were
characterized by IR, 1H NMR and 13C NMR spectral evidences. The newly synthesized
thiazolidinone compounds were tested for the antibacterial and anti fungal activity against
Escherichia coli (E.coli) and Aspergillus niger (A.niger) respectively. The testing results showed
moderate activity against E.coli and A.niger.
