Synthesis and characterization of thiourea based thiadiazolin derivatives

Abstract

The aim of the research project is to synthesize “Thiourea based thiadiazolin derivatives” and the goal of this research was successfully performed by three different steps: First: Thermal cyclization of thiosemicarbazide with substituted carboxylic acids to 5-phenyl 2-aminothiadiazole using catalytic amount of sulphuric acid. Second: Various Schiff‟s bases were synthesized from 5-phenyl -2-amino-1,3,4-thiadiazole and different substituted aromatic aldehydes. Third: Addition of ammonium thiocyanate to Schiff‟s bases afforded thioformimido thiadiazole derivatives. The structures of all the synthesized compounds were confirmed by spectral evidence.