Abstract:
Cellulose in microcrystalline form is the most popular excipient in pharmaceutical industry
for drugs formulation. Derivatized cellulose has also been used extensively in pharmaceutical
preparations such as ethyl cellulose, methyl cellulose, carboxymethyl cellulose, and
numerous other forms are used in oral, topical, and injectable formulations. Recent
development of controlled release drug delivery systems provides a uniform concentration or
amount of drug at absorption site, maintained plasma concentration within a therapeutic
range, minimizes the side effects and reduces the frequency of drug administration. Due to
the abundance, renewability, bio-compatibility of cellulose and its modified products have
received increasing interest in controlled drug delivery system. However, to the best of our
knowledge there are very few studies available on the binding interactions of the drugs with
microcrystalline cellulose (MCC) and its modified nano products such as nanocrystalline
cellulose (NCC) and dialdehyde derivatives of nanocrystalline cellulose (DANC). The
research work aims to investigate the interaction of a model drug ciprofloxacin with microand
modified nanocrystalline cellulose. The NCC prepared by an acid hydrolysis method
followed by ultrasonication and dialdehyde nanocrystalline cellulose(DANC) was prepared
from NCC by selective oxidation with sodium meta periodate, were shown to have
nanoscopic dimensions and exhibit a high degree of crystallinity. These crystallites bound
significant quantities of the water soluble, ionizable ciprofloxacin hydrochloride. DANC
binds relatively larger amount of ciprofloxacin hydrochloride compared to MCC and NCC.
The bounded drug released rapidly over one-hour period. The pH dependent release was
studied. The release of drug increases with the increase of pH of the solvent. At a certain pH
DANC release relatively large amount of ciprofloxacin hydrochloride compared to that of
NCC and MCC. The nature of binding and release of drug from MCC, NCC and DANC
suggest that DANC can be used as chemical anchor for further modification in the control
drug delivery system.
