Abstract:
Phthalimide(Isoindoline-1, 3-dione) derivatives have received attention due to their
antibacterial, antifungal, analgesic, antitumour, anxiolytic and anti HIV-1 activities.
Isoindoline 1,3-dione derivatives can be used as promising and effective drugs for the
treatment of different diseases such as AIDS, tumour, diabetes, multiple myeloma,
convulsion, inflammation, pain, bacterial infection.
A convenient, general and facile method for the synthesis of aroylsubstituted isoindoline-1, 3-
dione(7-11) from Phthalimide has been developed. The reactions of Phthalimide (1) with
aroylchlorides (2-6)were performed in the presence of Lewis acid (AlCl3) and also in absence of
acid in different solvents under mild conditions in good yield %.
Scheme-1:
2, 7 R= C6H4CH3 (p)
3, 8 R= C6H4Cl (p)
4, 9 R= C6H5
5, 10 R= CH3
1 2-5 7-10
Scheme-2:
6, 11 R= SO2C6H4CH3 (p)
All the synthesized compounds were characterized by IR, 1H-NMR and 13C-NMR spectra and
Elemental Analysis to establish the structure.
