Abstract:
Design, fabrication and characterization of bromopropionic acid derivatives, polymerization of derivatives, telechelic acetylene dicarbamate, and hydrogel(open chain polymer) have been reported in the first part of this thesis. Bromopropionic acid derivatives were synthesized by esterification using DCC/DMAP catalyst and then insertion of azide to ester productin DMF solvent. Polymerization (HEMA) of derivatives wasperformed under N2 atmosphere using initiator AIBN. A diacetylene precursor for click reaction was prepared using propargyl alcohol in triethylamine. The hydrogel was synthesized by a click reaction between azide derivative and diacetylene precursor using Cu catalyst. Polymerization (HEMA) determines the hydrogel formation. In the second synthetic route of hydrogel formation, we polymerized HEMA at very first step before esterification and azide insertion but obtained a similar kind of hydrogel. Derivatives and its polymer, and acetylene precursor were characterized by FTIR and 1H NMR spectroscopy. The hydrogel was characterized by FTIR and water absorption capacity. Thermal stability of hydogel was studied by thermogravimetric analyzer (TGA) and found good thermal stability. Computational studies show that polymerized compounds are highly bioactive molecule and can easily bind for drug delivery. In the second part of this thesis-design, fabrication and characterization of propargyl 2-bromopropionate (PBP), polymerization of PBP, and cyclic polymer have also been reported. PBP was also prepared by esterification reaction using DCC/DMAP catalyst. Polymerization of PBP was achieved by atom transfer radical polymerization method maintaining a strict N2 atmosphere using Cu catalyst. The cyclic polymer was synthesized by following a similar procedure (Click reaction) of hydrogel preparation. Characterization of synthesized compounds was done by FTIR and 1H NMR spectroscopy. The thermal stability of cyclic polymer was studied by thermogravimetric analyzer (TGA) and showed some greater thermal stability than hydrogels. Cyclic polymer could be a suitable candidate for drug design on the basis of its quantitative structure-activity relationships (QSAR) analysis.
