Synthesis of selected macrocyclic complexes and investigation of their antibacterial and antifungal activities

Abstract

The macrocyclic complex compounds of Ag(I) containing a ligand having tetraoxotetrahydrazin moity are synthesized by template condensation of malonodihydrazide (C3H8N4O2) with different aldehydes. The complexes are characterized on the basis of elemental analysis, UV-visible & IR spectroscopy, magnetic moment and conductance measurement and other physical properties. The IR spectrum study of the complex compounds suggests that ligand coordinates to metal ions through the nitrogen atoms from the tetraoxotetrahydrazin moity. Antibacterial activity of the derived complex compounds, as well as already used standard compound kanamycin, was tested on fourteen pathogenic bacteria. Given results were then compared to the efficacy of the Antibacterial activity of standard compound kanamycin used for control of these pathogenic bacteria