Synthesis of metallodendrimers based on diazine and triazine using cobalt (II) catalyst

Abstract

Dendrimers and metallodendrimers are large and complex molecules with very well defined chemical structures. From a polymer chemistry point of view, dendrimers are nearly perfect monodisperse macromolecules with a regular and highly branched three dimensional molecular architecture. Due to their versatile applications it was planned to develop a method to synthesis dendrimer and metallodendrimer compounds based on diazine and triazine with different acyl/arylchlorides. Firstly, a convenient method for the synthesis of metallodendrimer compounds 7-14 was developed from the reaction of triazine (melamine) and diazine (pyrimidine) with different acyl/arylchlorides 3-6 in the presence of (Ph3P)2CoCl2 at room temperature as shown in Scheme. Secondly, a method for the synthesis of dendrimer compounds 15-18 was developed from the reaction of triazine (melamine) and diazine (pyrimidine) with different acyl/arylchlorides 3, 5, 6 as shown in Scheme 2. Thirdly, metallodendrimers were also synthesized by treating the ligands (dendrimers) with (Ph3P)2CoCl2 in different solvents at room temperature as shown in Scheme 3. All the synthesized compounds were characterized by IR, 1H NMR, and 13C NMR to establish the structure. The SEM was taken for the analysis of surface morphology of the synthesized compounds. EDX was also taken for metal investigation as well as elemental analysis. The compounds were found having a homogeneous as well as non-homogeneous morphology with the particle size range from 0.5 μm to 9.75 μm. The particle sizes detected by SEM indicated that all the molecules were supramolecules type. Test for antimicrobial activity was also seen against 13 (thirteen) bacteria and 3 (three) fungi to find out the pharmaceutical importance of the compounds. In fact, the antibacterial activities of all the synthesized compounds, especially 8, 10, 12, 14, 15 and 16 were very promising. This positive result suggests that most of the compounds may contain potential antibacterial and antifungal properties.